We've known that sleep disturbances are among the best biological markers for depression, but this is the first time we've shown that those disturbances can show up decades before the depression.

Jack Chesbro was one of the best pitchers in the game at that time. He was known for his spitball. Cobb took the first pitch. Then he hit next pitch into the left-center gap.

My only relief is to sleep. When I'm sleeping, I'm not sad, I'm not angry, I'm not lonely, I'm nothing.

Not everyone who gets insomnia will eventually get depression. The next step is to try treating young patients who aren't depressed yet, but have a family history of depression and are having sleep disturbances.

Even after we compensated for confounding factors like family history of depression, coffee drinking, or their year in medical school, we still came out with a very clear change in risk.

Sometimes,
all you can do
is lie in bed,
and hope
to fall asleep
before
you fall apart.