This paper is important because it is the first study in humans that strongly suggests that calorie restriction may delay primary aging.

This is the first study to demonstrate that long-term calorie restriction with optimal nutrition has cardiac-specific effects that (delay or reverse) age-associated declines in heart function.

This is the first study to demonstrate that long-term calorie restriction with optimal nutrition has cardiac-specific effects that ameliorate age-associated declines in heart function.

Eating less, if it is a high-quality diet, will improve your health, delay aging, and increase your chance of living a long, healthy and happy life. This is the first paper to show that long-term calorie restriction with optimal nutrition has cardiac-specific effects that ameliorate the age-associated decline in diastolic function in humans. In other words, this is the first report ever to show that calorie restriction with optimal nutrition may delay primary aging in human beings.

We know people on calorie restriction will lose weight. But this study isn't a weight-loss study. We're hoping to learn more about whether calorie restriction can alter the aging process.

We know people on calorie restriction will lose weight. But this study isn't a weight-loss study. We're hoping to learn more about whether calorie restriction can alter the aging process.