This is the first study to demonstrate that long-term calorie restriction with optimal nutrition has cardiac-specific effects that ameliorate age-associated declines in heart function.

We know people on calorie restriction will lose weight. But this study isn't a weight-loss study. We're hoping to learn more about whether calorie restriction can alter the aging process.

This is the first study to demonstrate that long-term calorie restriction with optimal nutrition has cardiac-specific effects that (delay or reverse) age-associated declines in heart function.

This paper is important because it is the first study in humans that strongly suggests that calorie restriction may delay primary aging.

We know people on calorie restriction will lose weight. But this study isn't a weight-loss study. We're hoping to learn more about whether calorie restriction can alter the aging process.

I believe the diet has a powerful effect in modulating aging.