This is the first study to show this long-term relation between physical activity and dementia later in life.

It seems that physical activity had an even more pronounced effect among those with the susceptibility gene apoe4, the most important risk factor for Alzheimer's disease and dementia.

It may promote brain plasticity by a direct effect on the brain.

These findings may have wide implications for preventive healthcare. If an individual adopts an active lifestyle in youth, at midlife, this may increase their probability of enjoying both physically and cognitively vital years later in life.

The initial results of this phase I/II study in RA are very encouraging. We are looking forward to the ongoing development of HuMax-CD20 in RA.

The effects that we saw over the initial six-month study seem to be maintained over one year.