FastSaying
Our study provides a fundamentally new level of analysis by which we can better understand the actions of cocaine in brain-reward regions at the molecular level. It also points to new potential treatments for addiction.
Eric Nestler
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Study
Related Quotes
Our study provides insight into how chronic stress triggers changes in the brain that are much more long-lived than the effects of existing antidepressants.
— Eric Nestler
Stress
Study
One of the cardinal features of addiction is how long-lived it is, ... A key question in the field has been: By what mechanisms do drugs of abuse cause changes in the brain that last this long?
— Eric Nestler
Addiction
Without BDNF in the circuit, an animal can't learn that a social stimulus is threatening and respond appropriately.
— Eric Nestler
Animal
Appropriately
Circuit
The challenge is to find a way to inhibit BDNF signaling within the reward pathway specifically. The many genes we show that are regulated by BDNF or antidepressants in this pathway may provide clues.
— Eric Nestler
Challenge
Reward
Removal of BDNF before bullying, or treatment with antidepressants after bullying, both removed the behavioral abnormality observed.
— Eric Nestler
Treatment