I think the biggest problem in clinical trials is that they are underpowered. And that fundamentally, the studies are just too small.

I think Facebook's biggest problem is the glut of information that Facebook's power users are overwhelmed with.

I think the biggest problem of the 21st century is how to deal with minorities.

I think the biggest problem working with me would be that I'm an only child, and so I have an internal dialogue that goes on that I just assume you can hear.

My biggest problem is retaining the exact information.

Everybody tends to think I'm crazy, which is the biggest problem in my life.