I think Facebook's biggest problem is the glut of information that Facebook's power users are overwhelmed with.

My biggest problem is retaining the exact information.

I think the biggest problem in clinical trials is that they are underpowered. And that fundamentally, the studies are just too small.

I think the biggest problem of the 21st century is how to deal with minorities.

Everybody tends to think I'm crazy, which is the biggest problem in my life.

The biggest problem with dyslexic kids is not the perceptual problem, it is their perception of themselves. That was my biggest problem.