With this crystal structure, we've learned that Dicer serves as a molecular ruler, with a clamp at one end and a cleaver at the other end a set distance away, that produces RNA fragments of an ideal size for gene-silencing.
Jennifer Doudna
Related Knowing the structure of Dicer sets the stage for understanding how Dicer enzymes are involved in ot... JENNIFER DOUDNA By the side of the everlasting Why there is a Yes--a transitory Yes if you like, but a Yes. E.M. FORSTER When you put the clamp, the flat area and the cleaver together, you get a pretty good idea as to how... JENNIFER DOUDNA A thief stops stealing when he dies SOTONYE ANGA I'm a thinker. That is what I do, in great depth and detail, every waking moment of the day. I like ... BRIAN HERBERT Unification of differences is power. SHESH NATH VERNWAL Just know that I always have, and always will really love you, Lisa. Baby or no baby. Past or no pas... A. VIOLET END Look, that was some weird shit, you dying and then returning from the dead. I know it was no acciden... A. VIOLET END Obedience is bondage, if God wants to be adored he should make himself more loving. LAURA WHITCOMB If thinking is your fate, revere this fate with divine honour and sacrifice to it the best, the most... FRIEDRICH NIETZSCHE Life is a divine blessing for those who live life to add values in the lives of others. SEEMA BRAIN OPENERS Daring to dream is not difficult, it's making them come true that is hard... NANETTE L. AVERY Be careful of relying on the opinion of others, these are the same people that like liver. NANETTE L. AVERY (All the grief she had suffered over her lifetime had moulded her face into a mask of eternal sadnes... JEAN SASSON History is a wheel, for the nature of man is fundamentally unchanging. What has happened before will... GEORGE R.R. MARTIN If you have read this far in the chronicle of the Baudelaire orphans - and I certainly hope you have... LEMONY SNICKET I'm not saying that I'm better than anyone... I'm just saying that I'm one-of-a-kind. C LIONG Each man lives in his own universe and when he dies the world is over BANGAMBIKI HABYARIMANA We die a day at a time BANGAMBIKI HABYARIMANA I'll find you, don't worry. My body won't be with you all the time, but you'll always have my heart.... P.C. CAST Ladies,Please dress how you would like to be approached and talked to. Don't dress like a hoe and ex... UNKNOWN Interdependent Thinking is a true system view of the world. PEARL ZHU „Ein Mensch kann niemals Tier werden, er stürzt am Tier vorbei in den Abgrund MARLEN HAUSHOFER I like the word 'fuck'. The word means what it means, but it also means whatever you need it to mean... LISA GLATT Baby: an alimentary canal with a loud voice at one end and no responsibility at the other. ELIZABETH ADAMSON A baby is an alimentary canal with a loud voice at one end and no responsibility at the other JEROME K. JEROME Stairs to climb are difficult it takes time and effort and going down is easies job... what do I mea... DEYTH BANGER To change yourself you have to move from where you are and take a step, then you have to be willing ... BRENT M. JONES Only fools wait, and only tools bait. CRE There are approximately two trillion cells in the human body. You are never alone, there are always ... DWIGHT W. HAYES A stick and a string with a fly at one end and a fool at the
other. UNKNOWN Government is like a baby. An alimentary canal with a big appetite at one end and no sense of respon... JAMES RESTON Government is like a baby. An alimentary canal with a big appetite at one end and no sense of respon... RONALD REAGAN Government is like a baby: an alimentary canal with a big appetite at one end and no sense of respon... RONALD REAGAN The mightiest power of death is not that it can make people die, but that it can make the people you... FREDRIK BACKMAN Closed eyes, heart not beating, but a living love. AVIS COREA Well, you can't know it without something having been sneezed. A.A. MILNE We'll be Friends Forever, won't we, Pooh?' asked Piglet. Even longer,' Pooh answered.” ... A.A. MILNE You deserve to be with somebody, who knows you're the one, from that very first moment he lays eyes ... C. JOYBELL C. When you are a Bear of Very Little Brain, and you Think of Things, you find sometimes that a Thing w... A.A. MILNE Promise me you'll always remember: You're braver than you believe, and stronger than you seem, and s... CARTER CROCKER You must save what you can of your life; you musn't lose it all simply because you've lost a part. HENRY JAMES A fishing rod is a stick with a hook at one end and a fool at the other. SAMUEL JOHNSON Though we are terrorized by death, it's not different from birth, it just happens BANGAMBIKI HABYARIMANA Why ruin my sister's birthday simply because the entire planet was going to hell in a hand basket? T.C. BOYLE He had a theory that musicians are incredibly complex, and know far less than other artists what the... E.M. FORSTER Start out with an ideal and end up with a deal. KARL ALBRECHT Never give up on you. In order to make a difference you would have to somehow be different. JOHNNIE DENT JR. You're still lovely," Mor said a bit gently. Elain offered a half smile. "I suppose that war m... SARAH J. MAAS I liked myths. They weren't adult stories and they weren't children's stories. They were better than... NEIL GAIMAN Don't knock what you don't know. DEYON ANTEKO PITTER When you are called for a great duty because you have been given a great ability, do your very best ... ERNEST AGYEMANG YEBOAH One day there was a fly and a feather fly said to the feather buzzing about i am better than you are... GARY F EVANS... If we all took a minute to reflect upon the wrong we do we would be quite surprised or shocked.Inste... GARY F EVANS... Ants can carry twenty times their own body weight, which is useful information if you're moving out ... RON DARIAN The man I am today it's not the man of yesterday CHRISTOPHER FUDGE is a broken man an outlaw?" "More or less." Brienne answered. Septon Meribald ... GEORGE R.R. MARTIN The summer sun continued to rise in the sky and propel shocks of heat down on the city and the heavy... HUBERT SELBY JR. It appeared to Harriet that she was always the one who remembered having seen other people. They nev... ELIZABETH TAYLOR We were afraid this would set a precedent and end up nibbling away at our coastline. ELLIS ANDERSON A lot of teenagers write to me and say "I want to write a book. I want to get published." And those ... MAUREEN JOHNSON If you live to be a hundred, I want to live to be a hundred minus one day so I never have to live wi... JOAN POWERS Supposing a tree fell down, Pooh, when we were underneath it?' 'Supposing it didn't,' said Pooh... A.A. MILNE How lucky I am to have known somebody and something that saying goodbye to is so damned awful. EVANS G. VALENS Although it's great to appear to a feast, home is always sweet, though it may be lonely and cold lik... BANGAMBIKI HABYARIMANA You are not the happy, unthinking child you have always appeared to be, accepting everything at its ... AGATHA CHRISTIE Like a deep sad note played beneath the ocean waving through the orb the memories of ... PAWAN MISHRA This was a nightmare scenario for any bodyguard: stuck in the middle of a transparent tube, several ... EOIN COLFER The magnificence of such objects hardly pertains to the human. They live only in a world of icons an... ANGELA CARTER A fishing pole is a stick with a hook at one end and a fool on the other SAMUEL JOHNSON This book is its story, and mine. It is also yours. Because it won’t be long before the repercussi... JENNIFER A. DOUDNA Editas Medicine has an exclusive multimillion-dollar license with Juno Therapeutics to develop T cel... JENNIFER A. DOUDNA Let the wind blow, lad Let fall the deep snow, Let the stars fall, lad we'll answer ... JENNIFER A. NIELSEN Is he laughing with you or at you? If you have to ask then likely your being laughed at BRENT M. JONES Dreams, just dreams, it's all illusion BANGAMBIKI HABYARIMANA I'm like a recovering perfectionist. For me it's one day at a time. BRENE BROWN How do you shoot a 150-day movie? You shoot it one day at a time. DAVID FINCHER The issue isn't whether he loved you, it's how much. Too much. Love can be poison SARAH J. MAAS I am broken and healing, but every piece of my heart belong to you. SARAH J. MAAS He thinks he'll be remembered as the villain in the story. But I forgot to tell him that the villain... SARAH J. MAAS Night gathers, and now my watch begins. It shall not end until my death. I shall take no wife, hold ... GEORGE R.R. MARTIN Hodor," said Hodor. GEORGE R.R. MARTIN You do what you love, what you need SARAH J. MAAS I turned. Rhysand leaned against the archway into the sitting room, arms crossed, wings nowhere... SARAH J. MAAS In her experience it was very difficult to offer a man affection and kindness without giving him the... JOE HILL Death is tough for the people left behind on earth. PRATEEKSHA MALIK People in the real world always say, when something terrible happens, that the sadness and loss and ... FREDRIK BACKMAN When his wife was at his side, she was also in front of him, marking out the horizon of his life. No... MILAN KUNDERA I live nearby a graveyard, that's where I get all my inspiration for wisdom and life BANGAMBIKI HABYARIMANA If people just took it a day at a time, they'd be a lot happier. RICHARD BACHMAN She wasn't bitter. She was sad, though. But it was a hopeful kind of sad. The kind of sad that just ... STEPHEN CHBOSKY So, I guess we are who we are for alot of reasons. And maybe we'll never know most of them. But even... STEPHEN CHBOSKY I love my mom so much. I don't care if that's corny to say. I think on my next birthday, I'm going t... STEPHEN CHBOSKY We Are All Infinite STEPHEN CHBOSKY You can't just sit there and put everyone's lives ahead of yours and think that counts as love. You ... STEPHEN CHBOSKY I saw other people there. Old men sitting alone. Young girls with blue eye shadow and awkward jaws. ... STEPHEN CHBOSKY That one moment when you know you are not a sad story. You are ALIVE. STEPHAN CHBOSKY Somos quienes somos por un montón de razones.Quizás nunca conozcamos la mayoría de ellas.Pero aun... STEPHEN CHBOSKY Ambos dijeron que tomara asiento y parecían hablar en serio, así que me senté. STEPHEN CHBOSKY I know these will all be stories some day, and our pictures will become old photographs. We all beco... STEPHEN CHBOSKY
More Jennifer Doudna
One of the problems in the biotech world is the lack of women in leadership roles, and I'd like ... JENNIFER DOUDNA As mechanistic biologists, we are hoping that by understanding how the virus works at the molecular ... JENNIFER DOUDNA One can envisage taking cells from a patient with sickle-cell anaemia or an inherited blood disorder... JENNIFER DOUDNA I have always focused on basic research, motivated by a desire to understand the world. JENNIFER DOUDNA There's already a lot of active research going on using the Crispr technology to fix diseases li... JENNIFER DOUDNA I think that for a lot of women there's a subtle but unfortunately effective discouragement of w... JENNIFER DOUDNA Is it more ethical to edit embryos or to screen a lot of embryos and throw them away? I don't kn... JENNIFER DOUDNA I was kind of a nerdy, geeky type. And I loved math. People teased me about it. I felt pretty much l... JENNIFER DOUDNA The impression sometimes created among the public is that scientists are working away in their labs,... JENNIFER DOUDNA Understanding how Cas9 is able to locate specific 20-base-pair target sequences within genomes that ... JENNIFER DOUDNA We found that CAS9 has the ability to make a double-stranded break in DNA at sites that are programm... JENNIFER DOUDNA In the past, when we've tried gene therapy, we haven't had tools that have allowed targeted ... JENNIFER DOUDNA When you put the clamp, the flat area and the cleaver together, you get a pretty good idea as to how... JENNIFER DOUDNA Knowing the structure of Dicer sets the stage for understanding how Dicer enzymes are involved in ot... JENNIFER DOUDNA This book is its story, and mine. It is also yours. Because it won’t be long before the repercussi... JENNIFER A. DOUDNA Editas Medicine has an exclusive multimillion-dollar license with Juno Therapeutics to develop T cel... JENNIFER A. 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JENNIFER ANISTON Now that Scotty has entered the realm of myth, everyone wants to own him. And maybe they should. Doe... JENNIFER EGAN It's my experience that people are a lot more sympathetic if they can see you hurting, and for the m... JENNIFER NIVEN Stop trying to be less of who you are. Let this time in your life cut you open and drain all of the ... JENNIFER ELISABETH I can do this… I can start over. I can save my own life and I’m never going to be alone as long ... JENNIFER ELISABETH Don’t worry if people think you’re crazy. You are crazy. You have that kind of intoxicating insa... JENNIFER ELISABETH I do my best thinking at night when everyone else is sleeping. No interruptions. No noise. I like th... JENNIFER NIVEN Was I bitter? Absolutely. Hurt? You bet your sweet ass I was hurt. Who doesn't feel a part of their ... JENNIFER SALAIZ She's probably afraid you'll turn out like her and be married to someone you can't stand. 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JENNIFER JONES Going home and spending time with your family and your real friends keeps you grounded. JENNIFER ELLISON I don't regret what I've been through. I've had ups and downs, super highs and some real... JENNIFER LOPEZ I like to say, 'Chop suey's the biggest culinary joke that one culture has ever played on an... JENNIFER LEE I don't get sent anything strange like underwear. I get sent cookies. JENNIFER ANISTON I don't find it a struggle to maintain a healthy diet now as my palate has changed. I don't ... JENNIFER ELLISON Over the years, I have been a house painter, farm worker, paste-up artist, Easter Bunny, pizza deliv... JENNIFER MCMAHON One of the things I've started doing lately is tracking my dreams. I feel like there's a lot... JENNIFER CARPENTER In Congress, while the House's proposed defense budget calls for significant increases, it also ... JENNIFER GRANHOLM I am, you know, really fighting for myself and my life. And I think the message that I could give to... JENNIFER HOLLIDAY We might be shifting away from a Eurocentric view of the United States into something that's muc... JENNIFER LEE I listened to classic rock and roll, and punk rock. 'Goon Squad' provides a pretty accurate ... JENNIFER EGAN I had to learn how to chop wood actually - I don't think my dad would have let me go chop wood i... JENNIFER LAWRENCE Y’all might as well come on out,” I said. “I know you’re there. I can smell you.” “... JENNIFER ESTEP ... I succeeded at math, at least by the usual evaluation criteria: grades. Yet while I might have e... JENNIFER OUELLETTE Human nature defeats me sometimes, how greed and spite can lurk so divisively around the utmost cour... JENNIFER RYAN All the old school Young Adult novels inspired me. I grew up reading R.L. Stine, Christopher Pike, R... JENNIFER ARMENTROUT When you don't have anybody to take care of you, then you could go both ways: You could do whate... JENNIFER LAWRENCE I feel like I've started a new chapter in my life, and I need to leave the past behind. JENNIFER CAPRIATI I think I'm comedy-attractive, but it's never gonna be me and Charlize Theron up there. JENNIFER COOLIDGE I want to play a character I've never been before-a crazy serial killer like Charlize Theron in ... JENNIFER LAWRENCE I came on to the film with a very happy-go-lucky attitude which I think my character, Charlie, did w... JENNIFER SKY To become a classical ballerina, you have to move to New York when you're 12 or 11 and that beco... JENNIFER GARNER I'm trying to incorporate colour into my life. Until recently, everything in my closet was black... JENNIFER MORRISON We do a lot of crafting at our house. I don't even know how it got started because if you ask me... JENNIFER GARNER I get it. JENNIFER PLACE There's a moment when you realise all your worst fears have come true. When the fat girl stuffing he... JENNIFER TURNER I was raised in a Catholic family, spent twelve years in parochial schools, and had extremely fond m... JENNIFER HAIGH My cousin cleaned out a shotgun for me and let me carry it around the house, because he said, 'A... JENNIFER LAWRENCE The process was remarkably cathartic. I'd sit and listen to my father's voice - having not h... JENNIFER GRANT He'd forgiven who he needed to forgive, let go of what he needed to, and accepted himself as he ... JENNIFER GRANT I was very fortunate that my first novel captivated the imaginations of so many readers who asked fo... JENNIFER CHIAVERINI I like to have songs with me that have substance. That's missing from a lot of today's music... JENNIFER HUDSON I remember going on carriage rides with Dad when we'd visit. I think quiet L.A. suited him bette... JENNIFER GRANT I was feeling like a real misfit in middle school, but when I saw 'Wicked,' it made me feel ... JENNIFER DAMIANO