[Painkiller Jane centers on the title heroine, a young Marine officer who gains rapid self-healing powers after being exposed to a biochemical weapon.] They're slightly different, yet the same, ... Jane doesn't become a different person, necessarily, but things happen in her life that change her perspective on life in general, on who she is, and she starts to question a lot of things. So in her transformation into Painkiller Jane, she becomes a little more hardened and a little more skeptical of the world around her. I didn't treat them as two entirely different characters, but there definitely is a shift that happens.
— Emmanuelle Vaugier
HealingSelf