FastSaying
We had known that the expansion of the glutamine tract within Ataxin-1 probably interfered with normal clearance of Ataxin-1, meaning that it accumulated in cells.
Huda Y. Zoghbi
Clearance
Expansion
Interfered
Known
Normal
Probably
Within
Related Quotes
The overall picture we have now is that glutamine expansion causes some aspects of the pathology of SCA1 in part by enhancing the activity of the domain that is outside the glutamine repeat.
— Huda Y. Zoghbi
Causes
We had been accumulating clues that the glutamine tract expansion is clearly what is important for disease because that's the mutation. But we also concluded that there was something else beyond the glutamine that's really mediating the toxicity of the protein.
— Huda Y. Zoghbi
Disease
Importantly, such insights can now guide studies that focus on the normal function and interactions of these proteins and how they might be enhanced by disease-causing mutations. These studies could give better understanding of how the proteins cause disease.
— Huda Y. Zoghbi
Focus
I'm guess I'm up to about 70% of normal, which is a real relief. My doctor gave me clearance to go out in public again, so I've been able to go to the store and help out a little bit around the house.
— Wil Wheaton
Clearance
Doctor
Gave
If I saw him go up there, if I'd have known what was happening, I probably would have went up there with him.
— Larry Brown
Happening
Known
Probably