We can alleviate physical pain, but mental pain - grief, despair, depression, dementia - is less accessible to treatment. It's connected to who we are - our personality, our character, our soul, if you like.

The only antidote to mental suffering is physical pain.

Depression is a serious problem, but drugs are not the answer. In the long run, psychotherapy is both cheaper and more effective, even for very serious levels of depression. Physical exercise and self-help books based on CBT can also be useful, either alone or in combination with therapy. Reducing social and economic inequality would also reduce the incidence of depression.

The greatest evil is physical pain.

It doesn't get better," I said. "The pain. The wounds scab over and you don't always feel like a knife is slashing through you. But when you least expect it, the pain flashes to remind you you'll never be the same.

Marathons are hard because of the physical pain, the pounding on the muscles, joints, tendons.