The slightest sneeze, almost literally, can make the difference.

If it looks like we're going to lose a seat, that's really going to make everybody's life more difficult.

This is sickening, literally sickening,

An orgasm is just a reflex, like a sneeze

It's easy to make a buck. It's a lot tougher to make a difference.

I haven't the slightest idea who he is.