The differences between the two sides are very big. We mutually acknowledged each other's concerns.

There are big differences of opinion and stance on the issue.

This is something we have to talk more about.

The differences between the two sides are real but small, and they can be resolved by diplomatic means.

The differences between the sides are now much deeper and the chances for negotiations are much more remote. The only realistic steps may be Israeli unilateral steps.

He's a big factor for them; he's been a thorn in our sides the last couple of years.