That is a pretty clear signal that there is still something here. I'm hopeful that we will show significant results as we follow these women longer.

I can see how a lot of women might be confused.

I think we should have lowered expectations of what a lifestyle intervention trial can show over a relatively short period of time. Against a climate of less research funding overall, it's going to be harder to do these kinds of trials in the future.

I can see how a lot of women might be confused. People would like very clear results with a very clear health message, and, unfortunately, these results are not very clear.

These are secondary analyses and are exploratory to some extent.

These findings are reassuring for women who want to use these hormones around the age of menopause in the short term for the relief of symptoms.