Relatively few manufacturers have the luxury to choose a different product mix based on energy prices.

At the very least, I have to have very good visibility into my contract manufacturer in China as to any quality hiccups that might affect me. I need to get early warning of those, and potentially I may have to source locally to remain responsive to fluctuations in demand.

That may be the right time for you to say, 'OK I might need to move production to someone who is quite frankly better at manufacturing lower cost and make room for my next development drug to come through, and I'll move the product whose margins have now been eroded to a contract manufacturer.

What that means is you either have to invest in your own manufacturing, which can be an expensive proposition, particularly if you're not already a low-cost producer, or what you can start to do is think of using somebody else's flexibility or agility in manufacturing.

He is one of the most charismatic front guys of a band I've ever seen. It's his energy, the way he connects to the fans in the gigs where they get close to him.

We expect the Fed to focus on the risks to higher inflation caused by higher energy prices, supply-chain disruptions and the strain on resources resulting from the massive rescue, relief and rebuilding effort now underway.