One of the surprises in this study, where we put some of the people through the same protocol five times, is that there is substantial variation with a person on how they respond day to day. That can be due to a lot of potential sources, including environmental factors, that we don't understand.

Dr. Garret FitzGerald

People Study Surprises

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Although these results are in mice, not people, they raise an exciting possibility which can be tested in humans.

— Dr. Garret FitzGerald

PeoplePossibility

The amount of data we collected for this study was massive. There were no surprises, but some things did stand out more strongly than we expected.

— Dennis Soden

Up until now we have chronically underestimated the very substantial differences in the way individuals respond to the same dose of the same drug.

— Dr. Garret FitzGerald

ChronicallyDifferencesDose

Lots of genes could be important -- genes that determine how you absorb a drug, variations in one gene involved in breaking down the drugs, variations in the way that you excrete a drug.

— Dr. Garret FitzGerald

AbsorbDetermineDrug

I think aspirin would do exactly what you might expect -- attenuate, but not abolish the risk.

— Dr. Garret FitzGerald