Once you have a Down's syndrome child, you can't conform. In a way, you're free.

What having a Down's syndrome child isn't - and I feel very strongly about this - is a tragedy. All those pregnancy books you read when you are expecting refer to Down's syndrome as if it were the worst possible outcome, and it's not.

My blood runs cold when I hear the 'great news' that we have found a marker for the Down's syndrome gene, which means we can identify it more easily. Why is that good news? It's only good news if you're going to terminate.

The only way I'll ever run a marathon is if I'm involved in the administration.

I once had a friend who did the hair for sci-fi movies, and after a particularly bad break-up I stupidly went to her salon and told her she could do anything she liked. She dyed the bottom cherry red and the top peroxide blonde.

If you get 10,000 guys to put their ideal woman into a computer, it still comes out looking like Angelina Jolie.