It's clear to me that this has been sickeningly difficult and profoundly tragic,

It's clear to me that this has been sickeningly difficult, and profoundly tragic circumstance,

Sometimes in the most tragic situation, something just profoundly funny happens.

It seems fairly clear to me that had the sewage spill not occurred, he'd still be alive.

Like small cities, cruise ships experience crime ? from petty to profoundly tragic.

We need a vaccine,