It's a challenging differentiation whether the pain is really related to the heart or not.

Preferentially, as long as blood flows normal, the preferred fuel would be fatty acid. On the other hand, if you have decreased blood flow, the heart cleverly switches metabolism from fatty acid to sugar or glucose.

The beauty is that when blood flow returns back to [normal even though something is not quite right], the switch in metabolism persists. Therefore, we can image it much longer than what we could do [if we were just looking at blood flow].

We'd like to have an agent that we can inject at rest without having to put you on a treadmill that could actually [tell us] what happened five or eight hours or 30 hours ago.

Pain is the question mark turned like a fishhook in the human heart.

Whether it's a breast implant or a heart valve or a pain medication, it has to be proven safe.