It is the most detailed study yet describing the interplay of proteins that occur in cells during health and disease.

Using HPRD and several other databases, we have been able to develop a gold mine of new information for researchers seeking new ways of finding candidate genes involved in genetic diseases. And our demonstration that a protein's importance is not based on the number of interactions it has with other proteins is an important conceptual breakthrough. It eliminates a blind alley that could mislead researchers investigating the roles of specific proteins in the cell.

We proved they were valid. By linking computerized sleuthing to laboratory experiments to confirm those findings, we expect to be able to eventually fill in many blanks in human protein-protein interactions.

Genes are the blueprints for proteins, but proteins are where the action is in human life and health.

Our demonstration that a proteins importance is not based on the number of interactions it has with other proteins is an important conceptual breakthrough.

Genes are important because they are the blueprints for proteins, but proteins are where the action is in human life and health. This ability to find links between sets of proteins involved in different genetic disorders offers a novel approach for more rapidly identifying new candidate genes involved in human diseases.