In past experiments, meddling with this versatile pathway to exploit its beneficial effects on aging and life span inevitably invited a host of problems.

In the future, we may use this protein as a tool to study the genetic and metabolic requirements for extending longevity without causing diverse, wide-ranging effects on the development and maintenance of the physiological equilibrium in the organism.

So, the central question became whether we would be able to genetically manipulate one element of the pathway without disrupting its additional functions. In this regard, we thought that the life extending function of this pathway would be elusive, whereas the developmental and reproductive functions would be more amenable. We were delighted to find that Smk-1 proved to be specific for the one function we thought the most elusive.

It appears as if Wendy's missteps over the past two years could be ending and that the growing new product pipeline and easing beef costs could allow for same-store sales and margins to be bottoming.

In December 2005, Sun changed the way we think of software. In the past developers needed to be rich enough to buy software. But today, the barrier to entry is zero, all the key server software you need from us is available for free. You do not need to pay Sun until you need support from us.

We believe there's a difference in this team than in the past because of the way we work. We have a lot of team chemistry and it shows in the way we practice and play. Also, we're fighting hard to get the respect we deserve because we feel we've been under the radar for years.