In 1880 at the Military Hospital at Constantine, I discovered, on the edges of the pigmented spherical bodies in the blood of a patient suffering from malaria, filiform elements resembling flagellae which were moving very rapidly, displacing the neighbouring red cells.

I had the opportunity of making necropsies on patients dead from malignant fever and of studying the melanaemia, i.e., the formation of black pigment in the blood of patients affected by malaria.

In the tropical and subtropical regions, endemic malaria takes first place almost everywhere among the causes of morbidity and mortality, and it constitutes the principal obstacle to the acclimatization of Europeans in these regions.

Reticulocytes are terminally differentiating red blood cells that do not contain lysosome. Therefore, it was postulated that the degradation of hemoglobin in these cells is mediated by a non-lysosomal machinery.

This life is a hospital in which every patient is possessed with a desire to change his bed.

The population of the United States will, on account of the great influx of blood from Southeastern Europe, rapidly become darker in pigmentation, smaller in stature, more given to crimes of larceny, kidnapping, assault, murder, rape and sex immorality. And the ratio of insanity in the population will rapidly increase.