If the facts are contrary to any predictions, then the hypothesis is wrong no matter how appealing.

One finds the truth by making a hypothesis and comparing observations with the hypothesis.

It is absolutely essential that one should be neutral and not fall in love with the hypothesis.

Truth in science is always determined from observational facts.

Contrary to the dire predictions that have become popular over the last decade, the sky is *not* falling on the Y. This research clearly demonstrates that natural selection has effectively preserved regions of the Y chromosome that have no mechanisms with which to repair damaged genes.

There's two possible outcomes: if the result confirms the hypothesis, then you've made a discovery. If the result is contrary to the hypothesis, then you've made a discovery.