I think a reasonable dose is 81 milligrams a day, the amount in one baby aspirin.

In other words, 81 milligrams a day gives as much benefit as higher doses with potentially less risk of bleeding.

There are far more satisfying explanations for epidemic obesity. We have more calories available per capita per day than ever before in history. And more and more of those calories are packaged in highly processed, flavor-enhanced, processed foods.

The specific types of benefits differ in important ways … in women, by reducing the risk of ischemic stroke, and in men, by reducing the risk of heart attack.

The specific types of benefits differ in important ways & in women, by reducing the risk of ischemic stroke, and in men, by reducing the risk of heart attack.

Nobody has any ideas about the cause of the difference. It needs to be an important research priority for the future.