I am afraid that those comments go back to the late 80's. At that time I was a skeptic — the argument based on Koch's postulates to try to distinguish between cause and association. … Today I would regard the success of the many antiviral agents which lower the virus titers (to be expected) and also resolve the failure of the immune system (only expected if the virus is the cause of the failure) as a reasonable proof of the causation argument.

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During the time that Landsteiner gave me an education in the field of immunology, I discovered that he and I were thinking about the serologic problem in very different ways. He would ask, What do these experiments force us to believe about the nature of the world? I would ask, What is the most. simple and general picture of the world that we can formulate that is not ruled by these experiments? I realized that medical and biological investigators were not attacking their problems the same way that theoretical physicists do, the way I had been in the habit of doing.
Linus Pauling
biologyexperimentsimmunology