Before we opened, we did some research on the North Shore and we found that people wanted both Italian and seafood. Those are the two things we heard the most, and we thought, let's give 'em both.

The promise of stem cell research is that instead of prescribing medication and rehabilitation for people with heart attacks, strokes, spinal cord injuries and Alzheimer's disease, we will cure them.

Marc Jacobs is full of creative people and Louis Vuitton is again a name on the door, a name that has existed for many years but I'm a collaborator there and I bring in other people, other artists and I work with a great creative design team.

It's sometimes said that I'm rebellious and I do things to push people's buttons, but I just like the challenge.

But the customer is the final, final filter. What survives the whole process is what people wear. I'm not interested in making clothes that end up in some dusty museum.

My grandmother was amazing. She completely believed in me and was very encouraging. She would go to the supermarket or the butcher or wherever and tell people, 'My grandson is going to be the next Calvin Klein.'