Apathy is a trap. There is no challenge... so there is no reward. Remember, there is always free cheese in a mousetrap.

One of life's challenging realizations is that sometimes you outgrow your friends.

Rise to the challenge of bringing your dreams to life! Do not be discouraged by resistance, be nourished by it. Success is the experience of rising to the level of your true greatness.

The challenge is to find a way to inhibit BDNF signaling within the reward pathway specifically. The many genes we show that are regulated by BDNF or antidepressants in this pathway may provide clues.

The strong-minded rise to the challenge of their goals and dreams. The weak-minded become haters.

They're doing a terrific job. They have obviously high-profile positions with high expectations. We wanted to reward them.