A key issue in developmental biology at that time was the problem of how cells underwent differentiation, with most workers concentrating on explanations in terms of changes in enzyme and gene regulation.
Paul Nurse
Related And the actual achievements of biology are explanations in terms of mechanisms founded on physics an... MICHAEL POLANYI Evolution, cell biology, biochemistry, and developmental biology have made extraordinary progress in... JOHN TYLER BONNER There is no greater glory than to die for love. GABRIEL GARCíA MáRQUEZ Together they had overcome the daily incomprehension, the instantaneous hatred, the reciprocal nasti... GABRIEL GARCíA MáRQUEZ She would defend herself, saying that love, no matter what else it might be, was a natural talent. S... GABRIEL GARCíA MáRQUEZ i asked her why did you change? i am just like you she replied... SHIVANGI LAVANIYA When we can no longer change a situation, its the time to changed our self. GLENDA RADORES Isn't it funny that day by day nothing changes, but when you look back, everything is different. C.S. LEWIS Synthetic biology can help address key challenges facing the planet and its population. Research in ... CRAIG VENTER Both in Britain and America, huge publicity has been given to stem cells, particularly embryonic ste... ROBERT WINSTON There was a house at the foot of the tower, close to the thunder of the waves breaking against the c... GABRIEL GARCíA MáRQUEZ It will be in the convergence of evolutionary biology, developmental biology and cancer biology that... PAUL DAVIES This is not an issue of public forest management. It's an issue of private and state management. Thi... CHRIS WOOD In Hong Kong, I read Gabriel Garcia Marquez’s “Love in the Time of Cholera”, in which the hero... GRAEME SIMSION I realized that day that blessings come in a variety of shapes, colors, and sizes. CRAIG GROESCHEL The problem with Einstein's paradox is that it doesn't fold in biology?specifically, space radiation... FRANK CUCINOTTA She was intimidating and all I could do was sit back on the couch as she paced back and forth, slowl... IN THE MAKING Gratitude is one of the most powerful human emotions. Once expressed, it changes attitude, brightens... GERMANY KENT You deserve to be with somebody, who knows you're the one, from that very first moment he lays eyes ... C. JOYBELL C. Biology is far from understanding exactly how a single cell develops into a baby, but research sugge... KENNETH R. MILLER He shook his head in disbelief. He would cook and take her to his place. He was about to break two o... MARCIA WEBER MARTINS People, don't just seat there and wait. Sometimes you gotta change your daily routine if you're real... SEAN DAVZ The problem with the gene pool is that there's no lifeguard. DAVID GERROLD No one should let yesterday use up too much of today. Easy to say, hard to live. ANDREA HAIRSTON It may be the kind where, at the age of thirty, you sit in some bar hating everybody who comes in lo... J.D. SALINGER It is much more valuable to look for the strength in others. You can gain nothing by criticizing the... DAISAKU IKEDA the deceased don’t want you to forget about them. They just want you to move past it; not to dwell... JUSTIN PYFROM What's going on in biology, and is really very major, is we're understanding how really spectacular ... JAMES SHAPIRO There is always a solution to any problem. Find opportunities in any circumstance. Never become... LAILAH GIFTY AKITA Transitional periods in life are unsettling because a person’s latent fears constantly whisper war... KILROY J. OLDSTER Learn to appreciate every moment of your life, stop thinking of the future too much, you have a choi... AULIQ ICE The struggle is part of your story but Everything will be in place in the right situation at a perfe... NAPZ CHERUB PELLAZO If I died now," he said, "you would hardly remember me when you are my age." He said it for no ... GABRIEL GARCíA MáRQUEZ ...The Arabs I rode herding cattle with your father in the fifties and sixties would do a full day�... PATRICIA BRIGGS As has repeatedly been stated, the underlying hypothesis, which in a number of cases has been suppor... EDWARD LAWRIE TATUM Now is the only time we have, and the only time that we have any control over. RICHARD CARLSON We can leave a place behind, or we can stay in that place and leave our selfishness (often expressed... JOHN H. GROBERG I get it now, our body is made up of cells and cells are meant to keep something from leaving. Which... ANDONI GARCIA You're full of contradictions, Ms. Wallace." I looked up at him and arched a brow. "I'm a girl... TAMMARA WEBBER The only way he could have her was to shatter this stubborn faith of hers. In doing so, would he sha... FRANCINE RIVERS The benefits of the accomplished journey cannot be weighed in terms of perfect moments, but in terms... ELLA MAILLART The same tongue that tastes a cube of sugar when it is placed in a small cup of water and appreciate... ERNEST AGYEMANG YEBOAH I knew the ribosome was going to be the focus of Nobel prizes. It stands at the crossroads of biolog... VENKATRAMAN RAMAKRISHNAN The ones that most rang true to us were in the area of how companies look to stability and certainty... MARK MACLEOD Wake up to realities! Real life is all about real things! ERNEST AGYEMANG YEBOAH If I provide for this life and turn away from the Lord, I am wise for a moment, but lost forever. FRANCINE RIVERS The only way he could have her was to shatter this stubborn faith of hers. In doing so, would he sha... FRANCINE RIVERS All believers are members of the same body and should be viewed and treated that way. HENRY HON The goal in life is not to try and live forever, but to create something that will forever in people... KARON WADDELL Life is neither a glorious highlight reel nor a monstrous tragedy. Every day is a good day to live a... KILROY J. OLDSTER We dedicate most of the time worrying about our deficiencies and self-criticism instead of concentra... SUNDAY ADELAJA Look at what is happening here and think of it in terms of real life and how it affected the life of... DALLAS WILLARD It is unlikely that changes in telomeres are influencing the lifespan of the worm. That is because t... CYNTHIA KENYON God is the most beautiful, and beauty is the expression of God. If you can't appreciate beauty in th... AMIT RAY In simple terms, the data shows that in mammals each individual gene uses multiple different mechani... DAVID HUME I don't know if they're really like everybody else, or if they're able to pretend they are. MADELEINE L'ENGLE There is a process of social and of political differentiation going on in the real working class all... ERNEST MANDEL From 15 to 18 is an age at which one is very sensitive to the sins of others, as I know from recolle... FLANNERY O'CONNOR Get pass your past, be a presence in your present, and let no one refute your future. JOHNNIE DENT JR. When you you see no positive change take care of a negative change. OSCAR AULIQ-ICE JR Africa's informal economy is one of the most innovative and inventive environments in the world.... RICHARD ATTIAS Dive into the river of the present, but don't thrash about, go with the flow. JIM GENOVESE We were surprised by how sensitive cells were to small amounts and brief exposures to TNF. Our analy... ANDRE LEVCHENKO When we looked at gene expression, we found fairly small changes in 65 million years of the macaque,... YOAV GILAD To get over the past, you first have to accept that the past is over. No matter how many times you r... MANDY HALE One of the first papers I wrote at the University of Wisconsin, in 1977, was on stem cells. I realiz... BRUCE LIPTON We show how the normal function of the gene keeps dopamine cells from dying. If the gene is abnormal... DR. CURT FREED The moment I saw the model and heard about the complementing base pairs I realized that it was the k... SYDNEY BRENNER If I'm not thinking about one shit storm, I have to think about another. KAREN M. MCMANUS The drugs that are being developed are being developed to target specific protein or enzyme systems ... DAVID GREENWALD I still can't believe I danced with Gene Kelly. How lucky am I that I've been in movies wher... OLIVIA NEWTON-JOHN Imagine life as a game, a game that is filled with obstacles and hazards to overcome but sometimes y... GARY F EVANS... One's ideas must be as broad as Nature if they are to interpret Nature ARTHUR CONAN DOYLE Civilised life, you know, is based on a huge number of illusions in which we all collaborate willing... J.G. BALLARD The mystery of human existence lies not in just staying alive, but in finding something to live for. FYODOR DOSTOYEVSKY "in the embrace of the Embrace, we find ourselves and are Found" bluestflame SHAUN PARKER But, sir, isn't death a dreadful thing?" asked Malcolm. "That depends on whether a man re... GEORGE MACDONALD There is only one true aristocracy . . . and that is the aristocracy of passionate souls! TENNESSEE WILLIAMS The field of device regulation changes with this data, ERIC ROSE In 2008, the Nobel Prize in Chemistry was awarded for work done on a molecule called green fluoresce... EDITH WIDDER Easing back in her seat, Grace watched the children in the playground opposite, coats off, faces flu... KATHLEEN TESSARO When she was younger, she felt that he wanted to know everything about her, but she was sometimes af... MICHAEL STEIN Maya Angelou had the ability to glean inspiration out of pain. THE PROPHET OF LIFE Life begins somewhere and ends somewhere with time but to get somewhere with the life you have depen... ERNEST AGYEMANG YEBOAH In the beginning, there was nothing and from nothing came our species then behold the dawn of music.... GARY F EVANS... I have a harder time finding somebody. The problem is we were growing professionally during the year... KAREN CARPENTER History teachers help children climb mountains. JUST IN TIME FOR CHRISTMAS Right now, the techniques for gene therapy are kind of brute force. You put the gene in and hope it ... HARVEY LODISH Now is the only time we have, and the only time we have any control over. RICHARD CARLSON When you look at cells that don't yet have a specific function – aren't differentiated, compared t... SOPHIE LELIèVRE Science is beautiful when it makes simple explanations of phenomena or connections between different... STEPHEN HAWKING Mindfulness is observing the beauty of every moment unfolding before us. AMIT RAY In the time of the robber barons, my great grandfather insisted on reinvesting and sharing profits w... WILLIAM CLAY FORD, JR. Your most precious memories will focus on those you loved, those who loved you, and what you did tog... JAMES C. DOBSON The ultimate reason of things must lie in a necessary substance, in which the differentiation of the... GOTTFRIED LEIBNIZ The mark of a real man, is a man who can allow himself to fall deeply in love with a woman. But the ... C. JOYBELL C. The problem with hybrids is that in economic terms, they don't make a lot of sense. GAREL RHYS Stem cells tend to be smaller and have a slightly more compact shape than the differentiated cells. ... SEAN PALECEK One issue that the new pope should face is the problem on terrorism and the reasons for its being. I... FERNANDO FLORES It is only when we change the whole world of our inner world, that the whole world of the external w... DR. JACINTA MPALYENKANA, PH.D, MBA
More Paul Nurse
I decided that the University of Sussex in Brighton was a good place for this work because it had a ... PAUL NURSE This possibility bothered me as I thought it was not advisable to remain in one academic environment... PAUL NURSE My parents were born in Norfolk and spent their early years working in the big houses of that rural ... PAUL NURSE I was never very good at exams, having a poor memory and finding the examination process rather arti... PAUL NURSE I had a great time investigating the pigments of different mutant fruit flies by following experimen... PAUL NURSE Like many students, I found the drudgery of real experiments and the slowness of progress a complete... PAUL NURSE Better understanding of the natural world not only enhances all of us as human beings, but can also ... PAUL NURSE At age 11 in 1960, I moved to an academic state secondary school, Harrow County Grammar School for B... PAUL NURSE After an extensive interview he arranged for my weaknesses in foreign languages to be over-looked an... PAUL NURSE Therefore, I reasoned that study of the cell cycle responsible for the reproduction of cells was imp... PAUL NURSE I met my wife Anne who was a sociology student, and her influence together with activities associate... PAUL NURSE I have an idealistic view of science as a liberalising and progressive force for humanity. PAUL NURSE I was by far the youngest of the family, and at times it was like being an only child. PAUL NURSE My parents were neither wealthy nor academic, but we lived comfortably and they were always extremel... PAUL NURSE My main efforts focussed on trying to identify the rate controlling steps during the cell cycle. Cru... PAUL NURSE If we were zoning from scratch, we would not zone for six-story buildings surrounding a neighborhood... KARL NURSE We found some strange situations. For the year 2002, there were $250 million that the companies say ... CHRIS NURSE My hope is that we can do something that over time changes our community. Because I don't see signs ... KARL NURSE It would have been better before the boom, because buildings are obviously coming down at a pretty g... KARL NURSE The goal is that people will leave with a whole series of concrete actions they can take. KARL NURSE There are a lot of comfortably integrated neighborhoods. KARL NURSE Put work into your dreams. LESLEY D. NURSE My first paying job might have been doing a play, actually. My mom paid me to dress up as a flounder... PAUL DANO We can speak without voice to the trees and the clouds and the waves of the sea. Without words they ... PAUL TILLICH Show class, have pride, and display character. If you do, winning takes care of itself. PAUL BRYANT Mr. President how long must women wait to get their liberty? Let us have the rights we deserve. ALICE PAUL The shortage of buyers, which the world is suffering from, is readily understood, not as due to peop... PAUL DIRAC I do not see how a man can work on the frontiers of physics and write poetry at the same time. They ... PAUL DIRAC It seems that if one is working from the point of view of getting beauty in one's equations, and... PAUL DIRAC I should like to suggest to you that the cause of all the economic troubles is that we have an econo... PAUL DIRAC In science one tries to tell people, in such a way as to be understood by everyone, something that n... PAUL DIRAC Pick a flower on Earth and you move the farthest star. PAUL DIRAC Civilisation was built around wheat, around people settling down and not being nomadic. Baking is on... PAUL HOLLYWOOD As an opinion manager, a campaign consultant, fixing personality negatives is a lot easier than fixi... PAUL MANAFORT What we know about the global financial crisis is that we don't know very much. PAUL SAMUELSON No matter where you put me, I don't care if it is North Carolina, Florida, California, New York ... CHRIS PAUL The conscience of children is formed by the influences that surround them; their notions of good and... JEAN PAUL If my son is happy, then I am happy. CHRIS PAUL A great man is one who leaves others at a loss after he is gone. PAUL VALERY Each one of my budgets has taken a meat axe to foreign aid, because I think we ought to quit sending... RAND PAUL I don't think I've ever used the word 'gay rights,' because I don't really belie... RAND PAUL Does the owner of the restaurant own his restaurant? Or does the government own his restaurant? RAND PAUL People say America is exceptional. I agree, but it's not the complexion of our skin or the twist... RAND PAUL I think public awareness of how good vaccines are for kids and how they are good for public health i... RAND PAUL Some Libertarians argue that Western occupation fans the flames of radical Islam; I agree. But I don... RAND PAUL You can't solve a dignity problem with military force. RAND PAUL As a Christian, I believe in redemption. And I believe in second chances. RAND PAUL Mandatory minimum sentencing has disproportionately affected blacks, Hispanics and others who often ... RAND PAUL How will we defend ourselves if the Patriot Act expires? Well, perhaps we could just rely on the Con... RAND PAUL We must always embrace individual liberty and enforce the constitutional rights of all Americans-ric... RAND PAUL The United States has the highest incarceration rate in the world. Many of those people deserve to b... RAND PAUL The government has a history of not treating people fairly, from the internment of Japanese American... RAND PAUL The defeat of Obamacare will come from the realization that the very idea of a government-administer... RAND PAUL If our freedom is taken, the American dream will wither and die. RAND PAUL I grew up in a family that despised not only communism but collectivism, socialism, and any 'ism... RAND PAUL Naples is curiously chaotic and, if I'm honest, a bit dilapidated. It certainly has a 'lived... PAUL HOLLYWOOD How did we win the election in the year 2000? We talked about a humble foreign policy: No nation-bui... RON PAUL There is nothing wrong with describing Conservatism as protecting the Constitution, protecting all t... RON PAUL You don't have freedom because you are a hyphenated American; you have freedom because you are a... RON PAUL The obligations of our representatives in Washington are to protect our liberty, not coddle the worl... RON PAUL Capitalism should not be condemned, since we haven't had capitalism. RON PAUL All initiation of force is a violation of someone else's rights, whether initiated by an individ... RON PAUL When the federal government spends more each year than it collects in tax revenues, it has three cho... RON PAUL Our country's founders cherished liberty, not democracy. RON PAUL You wanna get rid of drug crime in this country? Fine, let's just get rid of all the drug laws. RON PAUL Maybe we ought to consider a Golden Rule in foreign policy: Don't do to other nations what we do... RON PAUL What is not conservative about saying, 'Don't go to war unless we go to war properly with a ... RON PAUL Well, I don't think we should go to the moon. I think we maybe should send some politicians up t... RON PAUL 1913 wasn't a very good year. 1913 gave us the income tax, the 16th amendment and the IRS. RON PAUL If you like small government you need to work hard at having a strong national defense that is not s... RON PAUL When one gets in bed with government, one must expect the diseases it spreads. RON PAUL The moral and constitutional obligations of our representatives in Washington are to protect our lib... RON PAUL There is only one kind of freedom and that's individual liberty. Our lives come from our creator... RON PAUL Legitimate use of violence can only be that which is required in self-defense. RON PAUL Exploiting people's emotions of fear, envy and anxiety is not hope, it's not change, it'... PAUL RYAN For the most ambitious young people, the corporate ladder is obsolete. PAUL GRAHAM I only think about the pitch. I want to do great. I want to be one of the best. I want to win titles... PAUL POGBA Shadow is a colour as light is, but less brilliant; light and shadow are only the relation of two to... PAUL CEZANNE A winner never whines. PAUL BROWN We'll lose more species of plants and animals between 2000 and 2065 than we've lost in the l... PAUL WATSON Hey, I'm like the Wayne Gretsky of the entertainment biz - I have other people do my dirty work ... PAUL FEIG If one takes pride in one's craft, you won't let a good thing die. Risking it through not pu... PAUL KEATING Baking is therapy. PAUL HOLLYWOOD Baking can be done with a few simple ingredients, so it's about simplicity and nostalgia - peopl... PAUL HOLLYWOOD When it comes to wildfires, 2013 wasn't a good year, which is why I'm especially proud that ... PAUL GOSAR It isn't hard to find injustice around us, but we must not let injustice smear the good deeds th... RAND PAUL Immigration is one of the leading contributors to population growth. PAUL WATSON Whatever I'm working on, the character I'm playing tends to slowly bleed into my own real li... PAUL RUDD It is one thing to photograph people. It is another to make others care about them by revealing the ... PAUL STRAND I am absolutely opposed to a national ID card. This is a total contradiction of what a free society ... RON PAUL The universe is built on a plan the profound symmetry of which is somehow present in the inner struc... PAUL VALERY There are souls which fall from heaven like flowers, but ere they bloom are crushed under the foul t... JEAN PAUL If slaughterhouses had glass walls, everyone would be a vegetarian. PAUL MCCARTNEY Dressing up is inevitably a substitute for good ideas. It is no coincidence that technically inept b... PAUL GRAHAM Winter is a season of recovery and preparation. PAUL THEROUX When I was in the Peace Corps I never made a phone call. I was in Central Africa; I didn't make ... PAUL THEROUX It is usually expensive and lonely to be principled. PAUL THEROUX Death is an endless night so awful to contemplate that it can make us love life and value it with su... PAUL THEROUX Travel magazines are just one cupcake after another. They're not about travel. The travel magazi... PAUL THEROUX When I started writing, I did have some idealised notion of my dad as a writer. But I have less and ... PAUL THEROUX An island is a fixed and finite piece of geography, and usually the whole place has been carved up a... PAUL THEROUX Because of my capacity for listening to strangers' tales, or the details of their lives, my pati... PAUL THEROUX Tourists don't know where they've been, travelers don't know where they're going. PAUL THEROUX A place that doesn't welcome tourists, that's really difficult and off the map, is a place I... PAUL THEROUX Hawaii is not a state of mind, but a state of grace. PAUL THEROUX Friendship is also about liking a person for their failings, their weakness. It's also about mut... PAUL THEROUX I am happy being what I am. PAUL THEROUX I like the idea of isolation, I like the idea of solitude. You can be connected and have a phone and... PAUL THEROUX The meaning of life is not to be discovered only after death in some hidden, mysterious realm; on th... PAUL KURTZ As a child I found railroad stations exciting, mysterious, and even beautiful, as indeed they often ... PAUL JOHNSON The British are coming. One if by land, two if by sea. PAUL REVERE Hunting is not a sport. In a sport, both sides should know they're in the game. PAUL RODRIGUEZ A man who is 'of sound mind' is one who keeps the inner madman under lock and key. PAUL VALERY As an artist I come to sing, but as a citizen, I will always speak for peace, and no one can silence... PAUL ROBESON The most important element of a free society, where individual rights are held in the highest esteem... RON PAUL Justifying conscription to promote the cause of liberty is one of the most bizarre notions ever conc... RON PAUL Things changed with the discovery of neutron stars and black holes - objects with gravitational fiel... PAUL DAVIES The Republican Party's history is rich and chock full of emancipation and black history. RAND PAUL Big and oppressive government has long been the enemy of freedom, something black Americans know all... RAND PAUL My style of comedy is very real and bittersweet, and sort of always on the verge of kind of being tr... PAUL FEIG I love Led Zeppelin and Black Sabbath and Guns N' Roses and AC/DC. PAUL DANO Segregation never brought anyone anything except trouble. PAUL HARRIS Now, actors get so familiarized with Eastern Europe. I never imagined I'd get as familiar with B... PAUL GIAMATTI Putin must be punished for violating the Budapest Memorandum, and Russia must learn that the U.S. wi... RAND PAUL A capitalist economy hums when leading businessmen are bubbling with animal spirits and are prepared... PAUL JOHNSON Real change occurs from the bottom up; it occurs person to person, and it almost always occurs in sm... PAUL HAWKEN I don't care if you're a Republican or a Democrat, there is something profoundly un-American... RAND PAUL I can still remember the feel in my hand of that most wonderful American coin ever minted, a nickel ... PAUL ENGLE Since I do not believe that there should be different recommendations for people living in the Bronx... PAUL FARMER The drink? Yes, I've had tough times in my life, especially the last year, regarding my ex-wife,... PAUL GASCOIGNE The human rights community has focused very narrowly on political and civil rights for many decades,... PAUL FARMER Man is this plural and collective unity in which the unity of destination and the differences of des... PAUL RICœUR Speaking personally as a filmmaker, I think encoded in Bond are a series of values about Britain, ab... PAUL GREENGRASS Wait, we can not break bread with you. You have taken the land which is rightfully ours. Years from ... PAUL RUDNICK I think I am typical in believing that the Peace Corps trained us brilliantly and then did little mo... PAUL THEROUX Brighton gives me the heebie-jeebies. When I'm near the seafront I can't sleep, I can't ... PAUL MCGANN I thought I was a hippie, bro. I wore Birkenstocks every day. I went to a Christian high school, so ... PAUL WALKER I'm Brian a lot more than I'm Paul Walker, which is awesome. When I hear, 'Hey Paul Walk... PAUL WALKER They get the faceless bureaucrats in Brussels and Strasbourg who have ruled and told the Brits how t... PAUL MANAFORT What happened with Brexit was people taking back control. PAUL MANAFORT We're close to losing our essential diversity. Look at our wheat crops - we rely on a handful of... PAUL WATSON Love is a spendthrift, leaves it arithmetic at home, is always in the red. PAUL SCHERER Man's great misfortune is that he has no organ, no kind of eyelid or brake, to mask or block a t... PAUL VALERY The future, like everything else, is not what it used to be. PAUL VALERY Our judgments judge us, and nothing reveals us, exposes our weaknesses, more ingeniously than the at... PAUL VALERY A man's true secrets are more secret to himself than they are to others. PAUL VALERY The purpose of psychology is to give us a completely different idea of the things we know best. PAUL VALERY War: a massacre of people who don't know each other for the profit of people who know each other... PAUL VALERY Serious-minded people have few ideas. People with ideas are never serious. PAUL VALERY Idleness is many gathered miseries in one name. JEAN PAUL My family is delighted every time I cook maitake. Our taste buds awaken in anticipation of its rich,... PAUL STAMETS If someone made fun of me, I'd be bummed out. But I'd play it like I thought it was hilariou... PAUL RUDD Bulk collection of phone records didn't find or stop the Tsarnaev brothers from the massacre in ... RAND PAUL The building block of every community is family. PAUL SINGER Having federal officials, whether judges, bureaucrats, or congressmen, impose a new definition of ma... RON PAUL The fictional world seems larger, seems to have more dimension and richness when, for example, the p... PAUL HARDING I can take pot or leave it. I got busted in Japan for it. I was nine days without it and there wasn&... PAUL MCCARTNEY And if small businesspeople say they made it on their own, all they are saying is that nobody else w... PAUL RYAN I used to say in the cabinet room, 'confidence is not like a can of Popeye spinach - you can'... PAUL KEATING Social media allows comics to bypass the gatekeepers and connect directly with people who will want ... PAUL PROVENZA What I tell founders is not to sweat the business model too much at first. The most important task a... PAUL GRAHAM I look a lot busier than I am, as I'm actually a rather sporadic, random person and I'll pla... PAUL MCCARTNEY Japan, Germany, and India seem to me to have serious writers, readers, and book buyers, but the Neth... PAUL THEROUX Women comedy is different than men comedy. Guy comedy is very aggressive, it's about insulting e... PAUL FEIG When my dog Buster died, I couldn't get over it. I was in bits. PAUL O'GRADY I read every book about Buster Keaton and Chaplin to see how they worked - it's all about dedica... PAUL MERTON There's something magical about film, it's the ultimate for me, because it's kind of per... PAUL MERTON If you look on the fungal genome as being soldier candidates protecting the U.S. as our host defense... PAUL STAMETS The point is - that Donald Trump has been making on the campaign trail is that he's financing hi... PAUL MANAFORT Donald Trump's whole candidacy from the time he started has been filled with myths by the media ... PAUL MANAFORT If you're running for president, you've got to do a lot of things to line up a candidacy. I&... PAUL RYAN The secret to understanding me is, I'm not trying to be anybody other than who I actually am. Pe... PAUL RYAN If any country was a mine-shaft canary for the reintroduction of cholera, it was Haiti - and we knew... PAUL FARMER These are Canadian and United States intelligence and law enforcement offices who are working in tea... PAUL CELLUCCI As Americans, we have traditionally been the optimists sporting the 'can-do' attitude. But w... PAUL TONKO Americans are falling out of the middle class, not into it. And they deserve relief. I absolute supp... PAUL TONKO The great thing about baseball is there's a crisis every day. GABE PAUL Courage consists not in blindly overlooking danger, but in seeing it, and conquering it. JEAN PAUL This meeting was like many of the meetings that I would go to over the course of two years. The only... PAUL O'NEILL Again and again, I've seen Bush turn a blind eye as his henchmen have leveled zealous attacks ag... PAUL BEGALA I'm not the least bit polished, I come from a blue collar background and I never thought I could... PAUL WALKER By the time my first album was out, I had been out in Jamaica three or four years, but I had hits ou... SEAN PAUL The Jam went through a phase of wearing satin jackets. But that was pre-getting signed and making it... PAUL WELLER It is possible for the assembly-line worker consigned to tightening the bolts on the transmission an... PAUL HAWKEN The more sand has escaped from the hourglass of our life, the clearer we should see through it. JEAN PAUL Traditionally, our ancestors boiled mushrooms in water to make a soothing tea. Boiling served severa... PAUL STAMETS Jazz came to America three hundred years ago in chains. PAUL WHITEMAN In science one tries to tell people, in such a way as to be understood by everyone, something that n... PAUL DIRAC It rarely adds anything to say, "In my opinion" -- not even modesty. Naturally a sentence is only y... PAUL GOODMAN The look of a king is itself a deed. JEAN PAUL A universe that came from nothing in the big bang will disappear into nothing at the big crunch. Its... PAUL DAVIES You can't be as old as I am without waking up with a surprised look on your face every morning: ... PAUL NEWMAN There still seems to be a lack of film for the baby boomer generation, if you'd like to call it ... PAUL EENHOORN As I've often said, you can shop online and find whatever you're looking for, but bookstores... PAUL KRUGMAN Politics is the art of preventing people from sticking their noses in things that are properly the... PAUL VALERY Politics isn't about big money or power games; it's about the improvement of people's lives PAUL WELLSTONE I've gone to Detroit. I've been to Ferguson; I've been to Baltimore, because I want our ... RAND PAUL I prize something that feels authentic. It's an undefinable thing, but I know it when I see it, ... PAUL GREENGRASS Cancer cells come pre-programmed to execute a well-defined cascade of changes, seemingly designed to... PAUL DAVIES While the struggle for religious liberty had proceeded without large-scale bloodshed in New England ... PAUL HARRIS